:root {
  --ink: #0b2945;
  --muted: #566b7e;
  --line: #dbe5eb;
  --paper: #ffffff;
  --pale: #f4f8fa;
  --green: #19562f;
  --serif: "Yu Mincho", "Hiragino Mincho ProN", "Hiragino Mincho Pro", "Noto Serif JP", serif;
  --sans: "Helvetica Neue", Arial, "Yu Gothic", sans-serif;
  --max: 956px;
  --hero-top-height: 342px;
  --hero-second-height: 200px;
  --hero-third-height: 200px;
  --hero-utility-height: 100px;
}

* { box-sizing: border-box; }
html { scroll-behavior: smooth; }
body { margin: 0; color: var(--ink); background: var(--paper); font-family: var(--serif); -webkit-font-smoothing: antialiased; }
a { color: inherit; text-decoration: none; }
a:focus-visible { outline: 2px solid #39799a; outline-offset: 4px; border-radius: 2px; }
img { display: block; max-width: 100%; }
.skip-link { position: fixed; z-index: 100; left: 1rem; top: -5rem; padding: .75rem 1rem; background: #fff; border: 1px solid var(--ink); }
.skip-link:focus { top: 1rem; }

.site-header { position: relative; z-index: 10; height: 76px; background: rgba(255,255,255,.97); }
.header-inner { height: 100%; max-width: var(--max); margin: 0 auto; display: flex; align-items: center; gap: 10px; }
.brand { width: 160px; flex: 0 0 160px; display: flex; flex-direction: column; align-items: flex-start; transition: opacity .25s ease, transform .25s ease; }
.brand img { width: 144px; height: auto; }
.brand span { margin: -3px 0 0 38px; font-size: 7px; white-space: nowrap; color: #294736; }
.global-nav { min-width: 0; flex: 1; margin-left: 0; display: flex; align-items: center; justify-content: space-between; gap: 12px; font-family: var(--serif); }
.global-nav > a:not(.contact-link) { display: grid; gap: 2px; text-align: center; white-space: nowrap; }
.global-nav > a:not(.contact-link) { position: relative; padding: 7px 0; transition: color .25s ease, transform .25s ease; }
.global-nav > a:not(.contact-link)::after { position: absolute; right: 50%; bottom: 1px; left: 50%; height: 1px; content: ""; background: linear-gradient(90deg, #6daac2, #19562f); transition: right .3s ease, left .3s ease; }
.global-nav b { font-size: 12px; font-weight: 500; letter-spacing: .015em; }
.global-nav a span { font-size: 9.5px; }
.contact-link { min-width: 108px; min-height: 36px; padding: 5px 15px; display: flex; flex-direction: column; align-items: center; justify-content: center; text-align: center; color: #fff; background: var(--green); border-radius: 19px; transition: color .25s ease, background-color .25s ease, box-shadow .25s ease, transform .25s ease; }
.contact-link b { font-size: 12px; letter-spacing: .08em; }
.contact-link small { margin-top: 2px; font-size: 9.5px; }
.menu-button { display: none; }

.hero { height: var(--hero-top-height); min-height: var(--hero-top-height); position: relative; overflow: hidden; background-color: #edf6f8; background-image: url("./assets/organelle-hero-visual.webp"); background-repeat: no-repeat; background-size: cover; background-position: center; }
.hero__inner { position: relative; max-width: var(--max); height: var(--hero-top-height); min-height: var(--hero-top-height); margin: 0 auto; padding: 53px 36px 22px; }
.eyebrow { margin: 0 0 38px; font-size: 9px; line-height: 1.7; letter-spacing: .28em; }
.hero h1 { margin: 0 0 18px; font-size: 35px; line-height: 1.45; font-weight: 400; letter-spacing: .12em; }
.hero__lead { margin: 0; font-size: 13px; line-height: 1.75; letter-spacing: .04em; }
.hero__sidecopy { width: 116px; position: absolute; top: 174px; right: 18px; }
.hero__sidecopy p { margin: 0; font-size: 10px; line-height: 1.55; letter-spacing: .1em; }
.hero__sidecopy span { width: 20px; height: 1px; display: block; margin: 11px 0; background: #71899a; }
.hero__sidecopy small { font-size: 9px; line-height: 1.65; }

.sections-shell { max-width: var(--max); margin: 0 auto; }
.feature { min-height: 186px; display: grid; grid-template-columns: 395px 1fr; gap: 0; padding: 8px 0; border-bottom: 1px solid var(--line); }
.feature__copy { min-width: 0; display: grid; grid-template-columns: 51px 1fr; padding-right: 28px; }
.section-number { align-self: stretch; padding-top: 2px; border-right: 1px solid var(--line); color: #b8bdc0; font-size: 31px; line-height: 1.1; font-weight: 300; }
.feature__text { padding: 1px 0 0 16px; }
.feature__en { margin: 0; font-size: 14px; line-height: 1.2; letter-spacing: .03em; }
.feature__jp { margin: 1px 0 11px; font-size: 9px; }
.feature h2 { margin: 0 0 8px; font-size: 19px; line-height: 1.45; font-weight: 400; letter-spacing: .04em; }
.feature__text > p:not(.feature__en):not(.feature__jp) { margin: 0 0 6px; color: #51697b; font-size: 14px; line-height: 1.65; }
.detail-link { display: inline-flex; align-items: center; gap: 14px; font-size: 10px; letter-spacing: .14em; }
.detail-link, .news__more { transition: color .25s ease, transform .25s ease; }
.detail-link span, .news__more span { width: 23px; height: 23px; display: inline-grid; place-items: center; border: 1px solid #7d98aa; border-radius: 50%; font-family: var(--sans); font-size: 13px; transition: color .25s ease, background-color .25s ease, border-color .25s ease, transform .25s ease; }
.feature-visual { min-width: 0; min-height: 170px; position: relative; align-self: stretch; overflow: hidden; background-repeat: no-repeat; background-size: cover; background-position: center; transition: filter .25s ease, box-shadow .25s ease, transform .25s ease; }
.feature-visual--who { background-image: url("./assets/section-01-research-facility.webp"); }
.feature-visual--technology { background-image: url("./assets/section-02-lysosome-visual.webp"); }
.feature-visual--research { background-image: url("./assets/section-03-research-evidence.webp"); }
.feature-visual--partnership { background-image: url("./assets/section-05-partnership-family.webp"); }
.feature-visual__caption { width: 116px; position: absolute; inset: 0 0 0 auto; padding: 35px 14px 12px; background: linear-gradient(90deg, rgba(245,249,250,.2), rgba(245,249,250,.92) 48%); }
.feature-visual__caption p { margin: 0; font-size: 9px; line-height: 1.5; letter-spacing: .09em; }
.feature-visual__caption span { width: 18px; height: 1px; display: block; margin: 10px 0; background: #7f96a5; }
.feature-visual__caption small { font-size: 8px; line-height: 1.55; }
.application-visuals { min-width: 0; align-self: center; display: grid; grid-template-columns: 273fr 278fr; gap: 8px; }
.application-card { min-width: 0; min-height: 149px; position: relative; overflow: hidden; background-repeat: no-repeat; background-size: cover; background-position: center; transition: filter .25s ease, box-shadow .25s ease, transform .25s ease; }
.application-card--air { background-image: url("./assets/section-04-air-environment.webp"); }
.application-card--beauty { background-image: url("./assets/section-04-beauty-skincare.webp"); }
.application-card__copy { position: relative; z-index: 1; padding: 48px 20px 14px; }
.application-card h3 { margin: 0 0 2px; font-size: 18px; line-height: 1.2; font-weight: 400; }
.application-card p { margin: 0 0 13px; font-size: 10px; }
.application-card__button { width: 100%; min-height: 34px; padding: 0 14px; display: flex; align-items: center; justify-content: space-between; border: 1px solid #8ba0ad; border-radius: 18px; background: rgba(255,255,255,.88); font-size: 10px; white-space: nowrap; transition: color .25s ease, background-color .25s ease, border-color .25s ease, box-shadow .25s ease, transform .25s ease; }
.application-card__button span { font: 14px var(--sans); }

.news { min-height: 112px; display: grid; grid-template-columns: 260px 1fr 130px; align-items: center; border-bottom: 1px solid var(--line); }
.news__title { align-self: stretch; display: grid; grid-template-columns: 51px 1fr; padding-top: 14px; }
.news__heading-link { margin-left: 16px; align-self: start; position: relative; transition: color .25s ease, transform .25s ease; }
.news__heading-link::after { width: 0; height: 1px; position: absolute; left: 0; bottom: -5px; content: ""; background: currentColor; transition: width .25s ease; }
.news__title h2 { margin: 2px 0 0; font-size: 10px; font-weight: 400; }
.news__list article { min-height: 32px; display: grid; grid-template-columns: 94px 106px 1fr; align-items: center; border-bottom: 1px solid #dbe3e7; font-size: 14px; }
.news__list article:last-child { border: 0; }
.news__list time { color: #52697b; font-size: 14px; }
.news__list span { justify-self: start; padding: 2px 8px; background: #eef3f5; color: #536879; font-size: 12px; }
.news__list p { margin: 0; }
.news__item-link { position: relative; display: inline; background-image: linear-gradient(currentColor, currentColor); background-position: 0 100%; background-repeat: no-repeat; background-size: 0 1px; transition: color .25s ease, background-size .3s ease; }
.news__more { display: inline-flex; justify-self: end; align-items: center; gap: 22px; font-size: 11px; letter-spacing: .1em; }

.utility-hero {
  height: var(--hero-utility-height);
  min-height: var(--hero-utility-height);
  position: relative;
  display: grid;
  align-items: center;
  overflow: hidden;
  background: #eaf3f6 url("./assets/news/news-hero-newspaper.webp") center 58% / cover no-repeat;
}
.utility-hero::after {
  position: absolute;
  inset: 0;
  content: "";
  pointer-events: none;
  background: linear-gradient(90deg, rgba(239,247,250,.92) 0%, rgba(239,247,250,.64) 37%, rgba(255,255,255,.08) 72%);
}
.utility-hero__inner {
  width: 100%;
  max-width: var(--max);
  margin: 0 auto;
  padding: 8px 12px 0;
  position: relative;
  z-index: 1;
}
.utility-hero__en { margin: 0 0 10px; font-size: 11px; line-height: 1.4; letter-spacing: .28em; }
.utility-hero h1 { margin: 0; font-size: 31px; line-height: 1.35; font-weight: 400; letter-spacing: .07em; }

.site-footer { min-height: 98px; background: linear-gradient(90deg, #f4f7ee, #f5f8f6 58%, #edf3ea); }
.footer-inner { max-width: var(--max); min-height: 98px; margin: 0 auto; display: grid; grid-template-columns: 220px 1fr; align-items: center; }
.brand--footer { width: 168px; }
.brand--footer img { width: 142px; }
.footer-meta { justify-self: end; display: grid; justify-items: end; gap: 10px; text-align: right; }
.footer-meta a { font-size: 10px; }
.footer-meta a { background-image: linear-gradient(currentColor, currentColor); background-position: 0 100%; background-repeat: no-repeat; background-size: 0 1px; transition: color .25s ease, background-size .25s ease; }
.footer-meta p { margin: 0; font-size: 8px; }

@media (max-width: 900px) {
  .site-header { height: 66px; }
  .header-inner { padding: 0 22px; }
  .brand { width: 155px; flex-basis: 155px; }
  .brand img { width: 136px; }
  .menu-button { margin-left: auto; width: 48px; height: 42px; padding: 0; display: grid; justify-items: center; align-content: center; gap: 7px; color: var(--ink); background: transparent; border: 0; font: 10px var(--serif); letter-spacing: .13em; }
  .menu-button__bars, .menu-button__bars::before, .menu-button__bars::after { width: 28px; height: 1px; display: block; background: currentColor; content: ""; transition: transform .2s ease, opacity .2s ease; }
  .menu-button__bars { position: relative; }
  .menu-button__bars::before { position: absolute; top: -6px; }
  .menu-button__bars::after { position: absolute; top: 6px; }
  .menu-button[aria-expanded="true"] .menu-button__bars { background: transparent; }
  .menu-button[aria-expanded="true"] .menu-button__bars::before { top: 0; transform: rotate(45deg); }
  .menu-button[aria-expanded="true"] .menu-button__bars::after { top: 0; transform: rotate(-45deg); }
  .global-nav { position: absolute; top: 66px; left: 0; right: 0; margin: 0; padding: 25px 22px 30px; display: none; grid-template-columns: 1fr 1fr; gap: 18px; background: rgba(255,255,255,.98); border-top: 1px solid var(--line); box-shadow: 0 12px 20px rgba(16,44,64,.08); }
  .global-nav.is-open { display: grid; }
  .global-nav > a:not(.contact-link) { text-align: left; }
  .global-nav b { font-size: 12px; }
  .global-nav a span { font-size: 10px; }
  .contact-link { width: 140px; }
  .contact-link small { font-size: 10px; }
  .hero { height: var(--hero-top-height); min-height: var(--hero-top-height); background-size: cover; background-position: center; }
  .hero__inner { min-height: var(--hero-top-height); padding: 55px 7vw 30px; }
  .hero h1 { font-size: clamp(28px, 7vw, 36px); }
  .hero__lead br { display: none; }
  .hero__lead { max-width: 34em; }
  .hero__sidecopy { right: 5vw; }
  .sections-shell { width: auto; margin: 0 6vw; }
  .feature { grid-template-columns: minmax(310px, 42%) 1fr; }
  .feature__copy { grid-template-columns: 48px 1fr; padding-right: 18px; }
  .news { grid-template-columns: 220px 1fr; padding-bottom: 18px; }
  .news__more { grid-column: 2; margin-top: 15px; }
  .footer-inner { padding: 25px 6vw; grid-template-columns: 190px 1fr; gap: 20px; }
  .utility-hero__inner { padding-right: 6vw; padding-left: 6vw; }
}

@media (max-width: 680px) {
  :root { --hero-top-height: 560px; --hero-second-height: 300px; --hero-third-height: 300px; --hero-utility-height: 150px; }
  .header-inner { padding: 0 18px; }
  .brand img { width: 130px; }
  .brand span { margin-left: 34px; font-size: 6px; }
  .global-nav { grid-template-columns: 1fr; }
  .hero { height: var(--hero-top-height); min-height: var(--hero-top-height); background-image: url("./assets/organelle-hero-visual.webp"); background-size: cover; background-position: 75% center; }
  .hero__inner { min-height: var(--hero-top-height); padding: 48px 7vw 28px; }
  .eyebrow { margin-bottom: 30px; }
  .hero h1 { font-size: clamp(27px, 8vw, 35px); line-height: 1.55; }
  .hero__lead { font-size: 14px; line-height: 1.9; }
  .hero__sidecopy { top: auto; right: 7vw; bottom: 34px; padding: 12px; background: rgba(244,249,250,.72); }
  .sections-shell { margin: 0; }
  .feature { display: flex; flex-direction: column; padding: 34px 6vw 42px; }
  .feature__copy { display: grid; grid-template-columns: 54px 1fr; padding: 0 0 27px; }
  .section-number { font-size: 29px; }
  .feature__text { padding-left: 17px; }
  .feature__en { font-size: 13px; }
  .feature__jp { font-size: 10px; }
  .feature h2 { font-size: 21px; }
  .feature__text > p:not(.feature__en):not(.feature__jp) { font-size: 16px; }
  .feature__text > p br { display: none; }
  .detail-link { margin-top: 8px; font-size: 12px; }
  .feature-visual { width: 100%; min-height: 220px; align-self: auto; }
  .feature-visual__caption { width: 132px; padding: 45px 16px 15px; }
  .feature-visual__caption p { font-size: 10px; }
  .feature-visual__caption small { font-size: 9px; }
  .application-visuals { width: 100%; grid-template-columns: 1fr; gap: 12px; }
  .application-card { min-height: 190px; background-size: cover; }
  .application-card__copy { padding: 62px 24px 20px; }
  .application-card h3 { font-size: 21px; }
  .application-card p { font-size: 12px; }
  .application-card__button { max-width: 255px; font-size: 12px; }
  .news { padding: 34px 6vw 40px; display: grid; grid-template-columns: 1fr; }
  .news__title { min-height: 70px; grid-template-columns: 54px 1fr; padding: 0; }
  .news__heading-link { margin-left: 17px; }
  .news__list article { padding: 11px 0; grid-template-columns: 118px 1fr; row-gap: 8px; font-size: 16px; }
  .news__list time { font-size: 16px; }
  .news__list span { font-size: 12px; }
  .news__list p { grid-column: 1 / -1; }
  .news__more { grid-column: 1; justify-self: start; margin-top: 22px; font-size: 12px; }
  .site-footer { min-height: 0; }
  .footer-inner { min-height: 58px; padding: 7px 6vw; display: grid; grid-template-columns: 130px 1fr; align-items: center; gap: 12px; }
  .brand--footer { width: 122px; flex-basis: auto; }
  .brand--footer img { width: 108px; }
  .brand--footer span { margin-top: -2px; margin-left: 28px; font-size: 5px; }
  .footer-meta { width: auto; display: grid; justify-items: end; align-self: center; gap: 3px; text-align: right; }
  .footer-meta a { font-size: 9px; }
  .footer-meta p { font-size: 7px; white-space: nowrap; }
  .utility-hero { min-height: var(--hero-utility-height); background-position: 60% center; }
  .utility-hero::after { background: linear-gradient(90deg, rgba(239,247,250,.92), rgba(239,247,250,.48) 72%, rgba(255,255,255,.08)); }
  .utility-hero__inner { padding: 10px 7vw 0; }
  .utility-hero__en { font-size: 11px; }
  .utility-hero h1 { font-size: 30px; }
}

@media (hover: hover) {
  .brand:hover { opacity: .78; transform: translateY(-1px); }
  .global-nav > a:not(.contact-link):hover { color: #23627a; transform: translateY(-2px); }
  .global-nav > a:not(.contact-link):hover::after { right: 0; left: 0; }
  .contact-link:hover { background: #103f27; box-shadow: 0 8px 18px rgba(25,86,47,.24); transform: translateY(-2px); }
  .detail-link:hover, .news__more:hover { color: #23627a; transform: translateX(3px); }
  .detail-link:hover span, .news__more:hover span { color: #fff; background: #23627a; border-color: #23627a; transform: rotate(-20deg); }
  .application-card__button:hover { color: #174d63; background: #fff; border-color: #487f96; box-shadow: 0 5px 14px rgba(19,72,95,.16); transform: translateY(-2px); }
  .feature-visual:hover, .application-card:hover { filter: saturate(1.06) brightness(1.02); box-shadow: 0 8px 20px rgba(22,65,84,.16); transform: translateY(-2px); }
  .application-card:hover .application-card__button { color: #174d63; background: #fff; border-color: #487f96; box-shadow: 0 5px 14px rgba(19,72,95,.16); transform: translateY(-2px); }
  .news__heading-link:hover { color: #23627a; transform: translateX(3px); }
  .news__heading-link:hover::after { width: 100%; }
  .news__item-link:hover { color: #23627a; background-size: 100% 1px; }
  .footer-meta a:hover { color: #23627a; background-size: 100% 1px; }
}

@media (prefers-reduced-motion: reduce) {
  html { scroll-behavior: auto; }
  *, *::before, *::after { transition-duration: .01ms !important; }
}